Bram van Bunnik

Introduction

I am a Postdoctoral researcher funded by:

My research focuses on the flow of antibiotic resistance genes between different reservoirs using mathematical models and Next Generation Sequencing. I am particular interested in the use of new techniques and technology to gain knowledge on the temporal and spatial spread of antibiotic resistance on all scales.

Using a combination of (experimental) data, mathematical modelling and whole genome sequencing data, I hope to gain better understanding of, and insight in, the mechanisms that underlie (both spatial and temporal) spread of diseases.

I received my MSc in Biology from the University of Groningen, The Netherlands, after which I started as a PhD-student at the department of Quantitative Veterinary Epidemiology of Wageningen University and Central Veterinary Institute in Lelystad, where I researched the spread of pathogen between spatially separated hosts.

Contact details

E-Mail:

bram.vanbunnik@ed.ac.uk

Tel:

+44 (0) 131 6505336

Office:

Ashworth 1 138.B

Publications

Meghan R. Perry, Hannah C. Lepper, Luke McNally, Bryan A. Wee, Patrick Munk, Amanda Warr, Barbara Moore, Pota Kalima, Carol Philip, Ana Maria de Roda Husman, Frank M. Aarestrup, Mark E. Woolhouse and Bram A. D. van Bunnik. Secrets of the hospital underbelly: patterns of abundance of antimicrobial resistance genes in hospital wastewater vary by specific antimicrobial and bacterial family Frontiers in Microbiology, Antimicrobials, Resistance and Chemotherapy. doi: https://doi.org/10.3389/fmicb.2021.703560

Bram A.D. van Bunnik, Alex L.K. Morgan, Paul Bessell, Giles Calder-Gerver, Feifei Zhang, Samuel Haynes, Jordan Ashworth, Shengyuan Zhao, Nicola Rose Cave, Meghan R. Perry, Hannah C. Lepper, Lu Lu, Paul Kellam, Aziz Sheikh, Graham F. Medley, Mark E.J. Woolhouse. Segmentation and shielding of the most vulnerable members of the population as elements of an exit strategy from COVID-19 lockdown. Philosophical Transactions of the Royal Society B 376 : 20200275-20200275 doi: 10.1101/2020.05.04.20090597

Morgan, Alex L. K., Woolhouse, Mark E. J., Medley, Graham F. and Bram A. D. van Bunnik. Optimizing time-limited non-pharmaceutical interventions for COVID-19 outbreak control. Philosophical Transactions of the Royal Society B: Biological Sciences, 376(1829): 20200282, 2021

Bryan A Wee, Dishon M Muloi, Bram A.D. van BunnikQuantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics. Clinical Microbiology and Infection. 2020 Sep. doi: 0.1016/j.cmi.2020.09.019

Bram A.D. van Bunnik, Alex L.K. Morgan, Paul Bessell, Giles Calder-Gerver, Feifei Zhang, Samuel Haynes, Jordan Ashworth, Shengyuan Zhao, Nicola Rose Cave, Meghan R. Perry, Hannah C. Lepper, Lu Lu, Paul Kellam, Aziz Sheikh, Graham F. Medley, Mark E.J. Woolhouse. Segmentation and shielding of the most vulnerable members of the population as elements of an exit strategy from COVID-19 lockdown. (Medrxiv preprint) doi: 10.1101/2020.05.04.20090597

Frank M Aarestrup, Bram A.D. van Bunnik. Comment on: Gross national income and antibiotic resistance in invasive isolates: analysis of the top-ranked antibiotic-resistant bacteria on the 2017 WHO priority list. Journal of Antimicrobial Chemotherapy.  2020 Jan. https://doi.org/10.1093/jac/dkz551

Meghan Perry, Bram van Bunnik, Luke McNally, Bryan Wee, Patrick Munk, Amanda Warr, Barbara Moore, Pota Kalima, Carol Philip, Ana Maria de Roda Husman, Frank Aarestrup, Mark Woolhouse. Secrets of the hospital underbelly: abundance of antimicrobial resistance genes in hospital wastewater reflects hospital antimicrobial use and inpatient length of stay. (medRxiv preprint). doi: 10.1101/19006858

Muloi D, Fèvre EM5, Bettridge J, Rono R, Ong'are D, Hassell JM, Karani MK, Muinde P, van Bunnik B, Street A, Chase-Topping M, Pedersen AB, Ward MJ, Woolhouse M. A cross-sectional survey of practices and knowledge among antibiotic retailers in Nairobi, Kenya. J Glob Health. 2019 Dec;9(2):010412. doi: 10.7189/jogh.09.020412. Pubmed PMID: 31489183

Dishon Muloi, John Kiiru, Melissa J. Ward, James M. Hassell, Judy M. Bettridge, Timothy P. Robinson, Bram A.D. van Bunnik, Margo Chase-Topping, Gail Robertson, Amy B Pedersen, Eric M. Fèvre, Mark E.J. Woolhouse, Erastus K. Kang'ethe, Samuel Kariuki,
Epidemiology of antimicrobial resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanising city, International Journal of Antimicrobial Agents, 2019, ISSN 0924-8579 (http://www.sciencedirect.com/science/article/pii/S0924857919302250)

Hendriksen RS, Munk P, Njage P, van Bunnik B, McNally L, Lukjancenko O, et al. Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature Communications. 2019;10(1):1124 (https://www.nature.com/articles/s41467-019-08853-3)

Muloi Dishon, Ward Melissa J., Pedersen Amy B., Fèvre Eric M., Woolhouse Mark E.J., and van Bunnik Bram A.D. Are Food Animals Responsible for Transfer of Antimicrobial-Resistant Escherichia coli or Their Resistance Determinants to Human Populations? A Systematic Review. Foodborne Pathogens and Disease 2018.(https://www.liebertpub.com/doi/full/10.1089/fpd.2017.2411)

van Bunnik BAD, Woolhouse MEJ. Modelling the impact of curtailing antibiotic usage in food animals on antibiotic resistance in humans. Royal Society Open Science 2017; 4. DOI: 10.1098/rsos.161067 (http://rsos.royalsocietypublishing.org/content/4/4/161067)

Gibbons, C.L., van Bunnik, B.A.D., Blatchford, O., Robertson, C., Porphyre, T., Imrie, L., Wilson, J., Fitzgerald, J.R., Woolhouse, M.E.J., and Chase-Topping, M.E. (2016). Not just a matter of size: a hospital-level risk factor analysis of MRSA bacteraemia in Scotland. Bmc Infectious Diseases 16, doi:10.1186/s12879-016-1563-6.

Woolhouse, M., Ward, M., van Bunnik, B., and Farrar, J. (2015). Antimicrobial resistance in humans, livestock and the wider environment. Philosophical Transactions of the Royal Society B-Biological Sciences 370, doi:10.1098/rstb.2014.0083.

van Bunnik B, Ciccolini M, Gibbons C, Edwards G, Fitzgerald R, McAdam P, Ward M, Laurenson I, Woolhouse M: Efficient national surveillance for health-care-associated infections. BMC Public Health 2015, 15(1):832. (http://www.biomedcentral.com/1471-2458/15/832)

Ward, M. J., Gibbons, C. L., McAdam, P. R., van Bunnik, B. A. D., Girvan, E. K., Edwards, G. F., Fitzgerald, J. R., Woolhouse, M. E. J. Time-Scaled Evolutionary Analysis of the Transmission and Antibiotic, Resistance Dynamics of Staphylococcus aureus Clonal Complex 398, Applied and environmental microbiology 80 2014, 7275-7282, doi:10.1128/aem.01777-14.

Bram A. D. van Bunnik, Amos Ssematimba, Thomas J. Hagenaars, Gonnie Nodelijk, Manon R. Haverkate, Marc J. M. Bonten, Mary K. Hayden, Robert A. Weinstein, Martin C. J. Bootsma, and Mart C. M. De Jong: Small distances can keep bacteria at bay for days. Proceedings of the National Academy of Sciences (PNAS) 2014 :1310043111v1-201310043 (http://www.pnas.org/content/early/2014/02/13/1310043111).

van Bunnik B, Hagenaars T, Bolder N, Nodelijk G, de Jong M: Interaction effects between sender and receiver processes in indirect transmission of Campylobacter jejuni between broilers. BMC Veterinary Research 2012, 8(1):123.

van Bunnik BAD, Katsma WEA, Wagenaar JA, Jacobs-Reitsma WF, de Jong MCM: Acidification of drinking water inhibits indirect transmission, but not direct transmission of Campylobacter between broilers. Preventive Veterinary Medicine 2012, 105(4):315-319, doi:10.1016/j.prevetmed.2012.03.007.

Beersma DGM, van Bunnik BAD, Hut RA, Daan S: Emergence of circadian and photoperiodic system level properties from interactions among pacemaker cells. Journal of Biological Rhythms 2008, 23(4):362-373, doi:10.1177/0748730408317992.

ResearchGate Profile: https://www.researchgate.net/profile/Bram_Van_Bunnik