Lu Lu

Current project

I am a postdoctoral researcher, funded by the Wellcome Trust VIZIONS (Vietnamese Initiative on Zoonotic Infections) grant. My project focuses on phylogenetics of viral pathogens using high throughput sequencing data obtained from several thousand samples collected from both humans and animals in Vietnam.

I would like to identify the spatio-temporal transmission and the cross-species transmission pathways of zoonotic viruses. I would also like to determine viral and epidemiological characteristics that impact the evolution, emergence and persistence of viral pathogens in human and animal populations.

Background

My PhD study (2011-2015) was in the Institute of Evolutionary Biology, University of Edinburgh. I was supervised by Professor Andrew J. Leigh Brown and Dr. Samantha J. Lycett. I systematically analysed full genome avian influenza A virus (AIV) sequences obtained from different bird species around the world by using developed phylogenetic methods. I described the structure of genetic diversity of AIV circulating in bird population and quantified the viral reassortment in the context of inter-subtypes, cross-host species and between-locations; I uncovered the strong associations between AIV evolution and virulence, host types, ecology and agro-economics impacts; I also evaluated the linkages between bird flyway and possible routes of disease transmission and spread.

I had my Master study (2008-2011) in the Institute of Microbiology, Chinese Academy of Science. My research projects focused on molecular evolution of Influenza A virus in poultry and pigs in China.

Contact details

E-Mail:

lu.lu@ed.ac.uk

Office:

Room 138, Ashworth 1

Publications

Lu Lu, Samantha J. Lycett, and Andrew J. Leigh Brown. Determining the genetic and phylogeographic origin of highly pathogenic avian influenza H7N3 in Mexico.PLos one. 2014, 9 doi: 10.1371/journal.pone.0107330

Lu Lu, Samantha J. Lycett, and Andrew J. Leigh Brown. Reassortment patterns of avian influenza viruses among different subtypes in internal segments. BMC Evolutionary Biology. 2014, 14:16  doi:10.1186/1471-2148-14-16

Yuhai Bi1, Lu Lu1, Jing Li, et al. Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice. Virology Journal. 2011, 8:505  doi: 10.1186/1743 -422X-8-505 (Co-first author)

Lu Lu, Yianbo Yin, George F Gao, Wenjun (Frank) Liu, et al. Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology. 2010, 186:191  doi: 10.1016/j.jcv.2010.07.018