Margo Chase-Topping

I am a senior researcher at the University of Edinburgh funded by the Wellcome Trust to work on the Innate immune response to H1N1pdm09 influenza A in pigs. This work is done in collaboration with the Pirbright Institute (link: https://www.pirbright.ac.uk/) analysing data from transmission studies in pigs.

EPIC (Centre of Expertise on Animal Disease Outbreaks) (link: http://www.epicscotland.org/). This work involves analysing data from a biosecurity survey carried out on farms in Scotland to develop a biosecurity score that will be useful in surveillance programmes to identify farms at increased risk of infection.

I collaborate with researchers from other Scottish Institutes such as the Roslin Institute (link:), the Moredun Research Institute (link: https://www.moredun.org.uk/),  the University of Glasgow (link: https://www.gla.ac.uk/researchinstitutes/bahcm/ ) and Scotland’s Rural College (link: https://www.sruc.ac.uk/info/120249/epidemiology_research_unit) on research projects funded by  Food Standards Scotland (link: https://www.foodstandards.gov.scot/publications-and-research/scientists-and-researchers/food-safety-research) looking at STEC in cattle and deer.

I also collaborate with the Parasite Immuno-Epidemiology Group (PIG) (link: http://pig.bio.ed.ac.uk/) at the University of Edinburgh.

Current Teaching

Contact details

Selected Publications

E. Sibanda, M.E. Chase-Topping, L.T. Pfavai, M.E. Woolhouse & F. Mutapi (2018) Evidence of a distinct group of Black African Systemic Lupus Erythematosus patients. BMJ Global Health, 3(2). DOI, 10.1136/bmjgh-2017-000661.

Porphyre, T., C. Correia-Gomes, M.E. Chase-Topping, K. Gamado, H.K. Auty, I. Hutchinson, A. Reeves, G.J. Gunn & M.E.J. Woolhouse (2017) Vulnerability of the British swine industry to classical swine fever. Scientific Reports, 7. DOI, 10.1038/srep42992

Gibbons, C.L., B.A.D. van Bunnik, O. Blatchford, C. Robertson, L. Imrie, J. Wilson, T. Porphyra, J.R. Fitzgerald, M.E.J. Woolhouse & M.E. Chase-Topping (2016) Not just a matter of size: A hospital-level risk factor analysis of MRSA bacteraemia in Scotland. Re-submitted to BMC Infectious Diseases, 16(222). DOI, 10.1186/s12879-016-1563-6

Dallman, T.,  P. Ashton,  L. Byrne, N. Perry, L. Petrovska, R. Ellis,  L. Allison, M. Hanson, A. Holmes, G. Gunn,  M. Chase-Topping,  M. Woolhouse, M. Grant, D. Gally,  J. Wain & C. Jenkins (2015). Applying phylogenomics to understand the emergence of Shiga Toxin producing Escherichia coli O157:H7 strains causing severe human disease in the United Kingdom. Microbial Genomics, 1(3). DOI, 10.1099/mgen.0.000029

Matthews, L., R. Reeve, D.L. Gally, J.C. Low, M.E.J. Woolhouse, S.P. McAteer, M.E. Locking, M.E. Chase-Topping, D.T. Haydon, L.J. Allison, M.F. Hanson, G.J. Gunn &  S.W.J. Reid (2013) Predicting the public health benefit of vaccinating cattle against Escherichia coli O157 . Proceedings of the National Academy of Sciences of the United States of America 110(40): 16265-16270.

Chase-Topping, M.E., I. Handel, B.M. Bankowski, N.D. Juleff, D. Gibson, S.J. Cox, M.A. Windsor, E. Reid, C. Doel, R. Howey, P.V. Barnett, M.E.J. Woolhouse & D. Charleston (2013). Understanding foot-and-mouth disease virus transmission biology: identification of the indicators of infectiousness. Veterinary Research 44

Chase-Topping, M.E., T. Rosser, L.J. Allison, E. Courcier,  J. Evans, I.J. McKendrick, M.C. Pearce, A. Caprioli, H. Karch, M.F. Hanson, K.G.J. Pollock, M.E. Locking, M.E.J. Woolhouse, L. Matthews, J.C. Low  & D.L. Gally (2012) Pathogenic potential to humans of bovine Escherichia coli O26 in Scotland. Emerging Infectious Diseases, 18(3): 439-448.

Charleston, B., B. Bankowski, S. Gubbins, M.E. Chase-Topping, D. Schley, R. Howey, P.V. Barnett, D. Gibson, N.D. Juleff & M.E.J. Woolhouse (2011) Relationship between clinical symptoms and transmission of an infectious disease and the implications for control. Science, 332:726-729.

Chase-Topping, M.E., D. Gally, C. Low, L. Matthews & M.E.J. Woolhouse (2008) Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157. Nature Reviews Microbiology 6(12): 904-912.

Chase-Topping, M.E., I.J. McKendrick, M.C. Pearce, P. MacDonald, L. Matthews, J. Halliday, L. Allison, D. Fenlon, J.C. Low, G. Gunn & M.E.J. Woolhouse (2007) Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms. Journal of Clinical Microbiology, 45: 1594-1603.

Matthews, L., J.C. Low, D.L. Gally, M.C. Pearce, D.J. Mellor, J.A.P. Heesterbeek, M. Chase-Topping, S.W. Naylor, D.J. Shaw, S.W.J. Reid, G.J. Gunn & M.E.J. Woolhouse (2006). Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control. Proceedings of the National Academy of Sciences USA 103: 547-552.

Chase-Topping, M.E., L.E.B. Kruuk , D. Lajous, S. Touzeau, L. matthews, G. Simm, J.D. Foster, R. Rupp, F. Eychenne, N. Hunter, J-M. Elsen & M.E.J. Woolhouse (2005) genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks. Journal of General Virology 86: 1229-1238.

Woolhouse, M., M. Chase-Topping, D. Haydon, J. Friar, L. Matthews, G. Hughes, D. Shaw, J. Wilesmith, A. Donaldson, S. Cornell, M. Keeling & B. Grenfell (2001) Epidemiology – foot-and-mouth disease under control in the UK. Nature 411(6835): 258-259.