Margo Chase-Topping

I am a senior researcher at the University of Edinburgh funded by the Wellcome Trust to work on the Innate immune response to H1N1pdm09 influenza A in pigs. This work is done in collaboration with the Pirbright Institute (link: analysing data from transmission studies in pigs.

EPIC (Centre of Expertise on Animal Disease Outbreaks) (link: This work involves analysing data from a biosecurity survey carried out on farms in Scotland to develop a biosecurity score that will be useful in surveillance programmes to identify farms at increased risk of infection.

I collaborate with researchers from other Scottish Institutes such as the Roslin Institute (link:), the Moredun Research Institute (link:,  the University of Glasgow (link: ) and Scotland’s Rural College (link: on research projects funded by  Food Standards Scotland (link: looking at STEC in cattle and deer.

I also collaborate with the Parasite Immuno-Epidemiology Group (PIG) (link: at the University of Edinburgh.

Current Teaching



Research Design and Statistical Analysis

Short course on Research Design for incoming PhD students in the Wellcome Trust funded Hosts, Pathogens and Global Health programme (link:

Statistics Masterclass

Workshop on statistics to new PhD students in the BBSRC EastBio Partnership (link:

Contact details



+44 (0) 131 6507263


Ashworth 1 138.B

Selected Publications

E. Sibanda, M.E. Chase-Topping, L.T. Pfavai, M.E. Woolhouse & F. Mutapi (2018) Evidence of a distinct group of Black African Systemic Lupus Erythematosus patients. BMJ Global Health, 3(2). DOI, 10.1136/bmjgh-2017-000661.

Porphyre, T., C. Correia-Gomes, M.E. Chase-Topping, K. Gamado, H.K. Auty, I. Hutchinson, A. Reeves, G.J. Gunn & M.E.J. Woolhouse (2017) Vulnerability of the British swine industry to classical swine fever. Scientific Reports, 7. DOI, 10.1038/srep42992

Gibbons, C.L., B.A.D. van Bunnik, O. Blatchford, C. Robertson, L. Imrie, J. Wilson, T. Porphyra, J.R. Fitzgerald, M.E.J. Woolhouse & M.E. Chase-Topping (2016) Not just a matter of size: A hospital-level risk factor analysis of MRSA bacteraemia in Scotland. Re-submitted to BMC Infectious Diseases, 16(222). DOI, 10.1186/s12879-016-1563-6

Dallman, T.,  P. Ashton,  L. Byrne, N. Perry, L. Petrovska, R. Ellis,  L. Allison, M. Hanson, A. Holmes, G. Gunn,  M. Chase-Topping,  M. Woolhouse, M. Grant, D. Gally,  J. Wain & C. Jenkins (2015). Applying phylogenomics to understand the emergence of Shiga Toxin producing Escherichia coli O157:H7 strains causing severe human disease in the United Kingdom. Microbial Genomics, 1(3). DOI, 10.1099/mgen.0.000029

Matthews, L., R. Reeve, D.L. Gally, J.C. Low, M.E.J. Woolhouse, S.P. McAteer, M.E. Locking, M.E. Chase-Topping, D.T. Haydon, L.J. Allison, M.F. Hanson, G.J. Gunn &  S.W.J. Reid (2013) Predicting the public health benefit of vaccinating cattle against Escherichia coli O157 . Proceedings of the National Academy of Sciences of the United States of America 110(40): 16265-16270.

Chase-Topping, M.E., I. Handel, B.M. Bankowski, N.D. Juleff, D. Gibson, S.J. Cox, M.A. Windsor, E. Reid, C. Doel, R. Howey, P.V. Barnett, M.E.J. Woolhouse & D. Charleston (2013). Understanding foot-and-mouth disease virus transmission biology: identification of the indicators of infectiousness. Veterinary Research 44

Chase-Topping, M.E., T. Rosser, L.J. Allison, E. Courcier,  J. Evans, I.J. McKendrick, M.C. Pearce, A. Caprioli, H. Karch, M.F. Hanson, K.G.J. Pollock, M.E. Locking, M.E.J. Woolhouse, L. Matthews, J.C. Low  & D.L. Gally (2012) Pathogenic potential to humans of bovine Escherichia coli O26 in Scotland. Emerging Infectious Diseases, 18(3): 439-448.

Charleston, B., B. Bankowski, S. Gubbins, M.E. Chase-Topping, D. Schley, R. Howey, P.V. Barnett, D. Gibson, N.D. Juleff & M.E.J. Woolhouse (2011) Relationship between clinical symptoms and transmission of an infectious disease and the implications for control. Science, 332:726-729.

Chase-Topping, M.E., D. Gally, C. Low, L. Matthews & M.E.J. Woolhouse (2008) Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157. Nature Reviews Microbiology 6(12): 904-912.

Chase-Topping, M.E., I.J. McKendrick, M.C. Pearce, P. MacDonald, L. Matthews, J. Halliday, L. Allison, D. Fenlon, J.C. Low, G. Gunn & M.E.J. Woolhouse (2007) Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms. Journal of Clinical Microbiology, 45: 1594-1603.

Matthews, L., J.C. Low, D.L. Gally, M.C. Pearce, D.J. Mellor, J.A.P. Heesterbeek, M. Chase-Topping, S.W. Naylor, D.J. Shaw, S.W.J. Reid, G.J. Gunn & M.E.J. Woolhouse (2006). Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control. Proceedings of the National Academy of Sciences USA 103: 547-552.

Chase-Topping, M.E., L.E.B. Kruuk , D. Lajous, S. Touzeau, L. matthews, G. Simm, J.D. Foster, R. Rupp, F. Eychenne, N. Hunter, J-M. Elsen & M.E.J. Woolhouse (2005) genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks. Journal of General Virology 86: 1229-1238.

Woolhouse, M., M. Chase-Topping, D. Haydon, J. Friar, L. Matthews, G. Hughes, D. Shaw, J. Wilesmith, A. Donaldson, S. Cornell, M. Keeling & B. Grenfell (2001) Epidemiology – foot-and-mouth disease under control in the UK. Nature 411(6835): 258-259.